Thymoquinone was investigated for its anti-oxidant, anti-inflammatory and anticancer activities in both in vitro and in vivo models since its first extraction in 1960s. Its anti-oxidant/anti-inflammatory effect has been reported in various disease models, including encephalomyelitis, diabetes, asthma and carcinogenesis. Moreover, thymoquinone could act as a free radical and superoxide radical scavenger, as well as preserving the activity of various anti-oxidant enzymes such as catalase, glutathione peroxidase and glutathione-S-transferase. The anticancer effect(s) of thymoquinone are mediated through different modes of action, including anti-proliferation, apoptosis induction, cell cycle arrest, ROS generation and anti-metastasis/anti-angiogenesis. The anti-tumor effects of thymoquinone have also been investigated in tumor xenograft mice models for colon, prostate, pancreatic and lung cancer. The combination of thymoquinone and conventional chemotherapeutic drugs could produce greater therapeutic effect as well as reduce the toxicity of the latter.
This site is a compilation of thymoquinone research across various types of cancers. Feel free to browse around and educate yourself on
this unique natural compound.
"Several studies have verified the beneficial properties of thymoquinone, particularly regarding its ability to thwart cancer cells in the pancreas, prostate and colon. These cancers tend to include inflammation, which thymoquinone has been proven especially adept at squashing. A 2009 study by the Kimmel Cancer Center in Philadelphia, Pennsylvania, determined that this compound can not only kill pancreatic cancer cells but also keep them from developing in the first place. This compound kept both cancer-causing histone deacetylases and several inflammation-causing cytokines from appearing..."